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These right-censored observations can pose technical challenges for estimating the model, if the distribution of
T
0
{\displaystyle T_{0}}
is unusual. 6 For example, the results of a clinical trial with mortality as the endpoint could be interpreted as a certain percentage increase in future life expectancy on the new treatment compared to the control. An alternative strategy is to perform parametric bootstrap, which requires modeling of the censoring distribution (Efron and Tibshirani, 1993, pp. Specifically, we defined the failure time as the minimum of the shedding times in blood and in urine. In addition, it is shown that the power is relatively larger when the minor allele frequency (MAF) is 0. 3, and 30 times for Cf = 0.
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The estimator solves the self-consistency equation
where a Check Out Your URL = min(a, b). In this study, the AFT UM-MDR method was proposed by extending the UM-MDR method to the survival phenotype. First, we check whether or not a type-I error is well preserved under the null hypothesis. 1, there are two kinds of type-I errors: uncorrected and corrected. We estimated the standard error using the Wald method based on 200 bootstrap data sets. The proposed methodology is demonstrated using both simulated and real data.
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In full generality, the accelerated failure time model can be specified as1
where
{\displaystyle \theta }
anchor
denotes the joint effect of covariates, typically
=
exp
(
[
1
X
1
+
+
p
X
p
]
)
{\displaystyle \theta =\exp(-[\beta _{1}X_{1}+\cdots +\beta _{p}X_{p}])}
. .